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KMID : 0812020090150010015
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Korean Journal of Neurogastroenterology and Motility
2009 Volume.15 No. 1 p.15 ~ p.22
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Prevalence of Eosinophilic Esophagitis with Dysphagia and Reflux Related Symptoms in Korean Patients
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Abstract
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Background/Aims :In adult patients with dysphagia, food impaction and non-responsiveness to proton pump inhibitor, eosinophilic esophagitis (EoE) should be considered. We aimed to investigate the prevalence of EoE in Korean patients.
Methods :From July 2007-February 2009, 108 patients presenting with dysphagia and reflux related symptoms were enrolled. The mid-esophageal region was randomly biopsied.
Results :Of the 108 patients, two cases of EoE, two cases of eosinophilic enterocolitis and one case of drug-induced eosinophilic enterocolitis were diagnosed. The most frequent symptom was dysphagia (37.9%), followed by epigastric pain (25.9%) and regurgitation (23.1%). Endoscopic findings of eosinophilic infiltration in the esophagus were ring esophagus, linear furrow, nodularities and whitish patches. Histologic findings showed chronic inflammation (33.3%), epithelial cell hyperplasia (16.6%), eosinophilic infiltration (3.7%) and a few eosinophil infiltration (1.8%).
Conclusion : EoE was detected in 1.8% in Korean patients with dysphagia and reflux related symptoms. Esophageal random biopsy should be considered especially in young patients with a history of allergic disease and esophageal symptoms. (Kor J Neurogastroenterol Motil 2009;15:15-22)
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KEYWORD
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Dysphagia, Gastroesophageal reflux, Eosinophil, Eosinophilic esophagitis
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